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Oxycodone, sold under the brand names Roxicodone and OxyContin (which is the extended release form) among others, is an opioid medication used for treatment of moderate to severe pain, and a common drug of abuse.[12][13] It is usually taken by mouth, and is available in immediate-release and controlled-release formulations.[12] Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation.[12] In the United Kingdom, it is available by injection.[14] Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.[12

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Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.[12] Severe side effects may include addiction, dependence, hallucinations, respiratory depression (a reduction in breathing), bradycardia, and low blood pressure.[12] Those allergic to codeine may also be allergic to oxycodone.[12] Use of oxycodone in early pregnancy appears relatively safe.[12] Opioid withdrawal may occur if rapidly stopped.[12] Oxycodone acts by activating the μ-opioid receptor.[15] When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.[16]

Oxycodone was first made in Germany in 1916 from thebaine.[17] It is available as a generic medication.[12] In 2018, it was the 48th most commonly prescribed medication in the United States, with more than 16 million prescriptions.[18][19] A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.[13][20]

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